Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis

Neoandrographolide inhibits mature osteoclast differentiation to alleviate bone loss and treat osteoporosis

BackgroundOsteoporosis (OP), as the prevalent systemic metabolic bone disease worldwide, progresses insidiously and slowly. The clinical discomfort and complications associated with OP impose a significant burden on patients. Therefore, finding more effective treatments for OP remains an urgent chal...

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Bibliographic Details
Main Authors: Kai Tang, Wei Deng, Zhiying Huang, Simin Chen, Zilin Zhu, Shukun Lin, Lubin Zhong, Quanxin Zheng, Wenhua Zhao, Zhida Zhang, Ling Mo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
neoandrographolide
osteoclastogenesis
MAPK
NF-κB
PI3K/AKT
PPARγ
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1466057/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1466057/full

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