Truncated LKB1 nonenzymatically enhances Fas-induced apoptosis by acting as a surrogate of Smac

Truncated LKB1 nonenzymatically enhances Fas-induced apoptosis by acting as a surrogate of Smac

Abstract Although liver kinase B1 (LKB1) has been established as a tumor suppressor kinase, its mechanism of action is incompletely understood. Here we describe a novel nonenzymatic function of LKB1 in cell death induced by Fas/CD95. In BID knockout HeLa cells, inactivation of mitochondrial outer me...

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Main Authors: Yutaro Yamada, Mei Tsuchida, Takuya Noguchi, Takumi Yokosawa, Maki Mitsuya, Tatsuya Shimada, Daisuke Oikawa, Yusuke Hirata, Fuminori Tokunaga, Pascal Schneider, Atsushi Matsuzawa
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02570-1
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https://doi.org/10.1038/s41420-025-02570-1

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