Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay

Abstract Microtubules, built from heterodimers of α- and β-tubulins, control cell shape, mediate intracellular transport, and power cell division. The concentration of αβ-tubulins is tightly controlled through a posttranscriptional mechanism involving selective and regulated degradation of tubulin-e...

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Bibliographic Details
Main Authors: Alina Batiuk, Markus Höpfler, Ana C. Almeida, Deryn Teoh En-Jie, Oscar Vadas, Evangelia Vartholomaiou, Ramanujan S. Hegde, Zhewang Lin, Ivana Gasic
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54036-0
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