Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation

Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation

Mitochondria adapt to the cell proliferative demands induced by growth factors through dynamic changes in morphology, distribution, and metabolic activity. Galectin-8 (Gal-8), a carbohydrate-binding protein that promotes cell proliferation by transactivating the EGFR-ERK signaling pathway, is overex...

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Bibliographic Details
Main Authors: Adely de la Peña, Claudio Retamal, Francisca Pérez-Molina, Nicole Díaz-Valdivia, Francisco Veloso-Bahamondes, Diego Tapia, Jorge Cancino, Felix Randow, Alfonso González, Claudia Oyanadel, Andrea Soza
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:European Journal of Cell Biology
Subjects:
Galectin-8
Mitochondrial dynamics
Proliferation
Mitophagy
Glycosylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933525000135
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