Therapeutic Drug Monitoring of Everolimus Using Volumetric Absorptive Microsampling and Quantitative Dried Blood Spot Methods with LC-MS/MS in Adult Solid Organ Transplant Recipients: An Analytical and Clinical Comparative Study

Therapeutic Drug Monitoring of Everolimus Using Volumetric Absorptive Microsampling and Quantitative Dried Blood Spot Methods with LC-MS/MS in Adult Solid Organ Transplant Recipients: An Analytical and Clinical Comparative Study

Everolimus (EVE), an mTOR inhibitor, is widely used in solid organ transplantation (SOT) because of its immunosuppressive properties. Due to its narrow therapeutic window and significant pharmacokinetic variability, therapeutic drug monitoring (TDM) is essential for achieving optimal outcomes. We de...

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Main Authors: Arkadiusz Kocur, Bartosz Olkowski, Mateusz Moczulski, Dorota Miszewska-Szyszkowska, Olga Maria Rostkowska, Katarzyna Polak, Katarzyna Korniluk, Teresa Bączkowska, Magdalena Durlik, Tomasz Pawiński
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
everolimus
qDBS
VAMS
LC-MS/MS
solid organ transplantation
Online Access:https://www.mdpi.com/1420-3049/30/15/3139
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