JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain

JMJD3 deficiency disturbs dopamine biosynthesis in midbrain and aggravates chronic inflammatory pain

Abstract Midbrain dopamine (mDA) neurons participate in a wide range of brain functions through an intricate regulation of DA biosynthesis. The epigenetic factors and mechanisms in this process are not well understood. Here we report that histone demethylase JMJD3 is a critical regulator for DA bios...

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Main Authors: Xi-Biao He, Fang Guo, Wei Zhang, Jiacheng Fan, Weidong Le, Qi Chen, Yongjun Ma, Yong Zheng, Sang-Hun Lee, Hui-Jing Wang, Yi Wu, Qinming Zhou, Rui Yang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Acta Neuropathologica Communications
Subjects:
Dopamine biosynthesis
Midbrain dopamine neuron
Transcriptional regulation
Chronic inflammatory pain
Epigenetic control
Online Access:https://doi.org/10.1186/s40478-024-01912-x
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https://doi.org/10.1186/s40478-024-01912-x

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