In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy

In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy

Abstract Background and purpose The tumor microenvironment (TME) is widely acknowledged as a pivotal regulator of cancer progression. However, the dualistic role of tertiary lymphoid structures (TLSs), which serve as critical immune hubs within the TME, remains incompletely characterized, particular...

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Main Authors: Maedeh Radandish, Niloofar Mashhadi, Amir Hossein Aghayan, Motahareh Taghizadeh, Sara Salehianfard, Sheida Yahyazadeh, Omid Vakili, Somayeh Igder
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Experimental Hematology & Oncology
Subjects:
Neoplasms
Cancer immunotherapy
Tumor microenvironment
Stromal cell immunomodulation
Tertiary lymphoid structures
Tumor infiltration
Online Access:https://doi.org/10.1186/s40164-025-00695-8
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https://doi.org/10.1186/s40164-025-00695-8

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