The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway

The pathogenesis of sepsis-associated encephalopathy (SAE) involves many aspects, including intracellular peroxidative stress damage, mitochondrial dysfunction, and cell apoptosis. In this study, we mainly explored the influence of P2X7R on the cognitive function of SAE and its molecular mechanism....

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Bibliographic Details
Main Authors: Kaifang Wang, Meiyan Sun, Zhaodong Juan, Jianxin Zhang, Yingui Sun, Guizhi Wang, Chunling Wang, Yanjing Li, Wenwen Kong, Lulu Fan, Yue Zhang, Hongxiang Zhao, Xiaoyong Zhao
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.1155/2022/3777351
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