Rapid and One-Pot Synthesis of Aryl Ynamides from Aryl Alkynyl Acids by Metal-Free C-N Cleavage of Tertiary Amines

Rapid and One-Pot Synthesis of Aryl Ynamides from Aryl Alkynyl Acids by Metal-Free C-N Cleavage of Tertiary Amines

Herein a rapid, metal-free, and highly efficient synthesis of aryl ynamides from aryl alkynyl acids has been described. This approach, utilizing tertiary amines as an amino source via metal-free C-N cleavage, enabled the construction of a diverse range of aryl ynamides with medium to excellent yield...

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Bibliographic Details
Main Authors: Yong Liu, Xiaoyong Liu, Hongwei Li, Shengmei Guo
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
aryl ynamide
C-N bond cleavage
tertiary amine
one-pot synthesis
Online Access:https://www.mdpi.com/1420-3049/30/14/2955
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