Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.

Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.

A series of mini-antibodies (monovalent and bivalent Fabs) targeting the conserved internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41 has been previously constructed and reported. Crystal structures of two closely related monovalent Fabs, one (Fab 8066) broadly neutralizing ac...

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Bibliographic Details
Main Authors: Elena Gustchina, Mi Li, Rodolfo Ghirlando, Peter Schuck, John M Louis, Jason Pierson, Prashant Rao, Sriram Subramaniam, Alla Gustchina, G Marius Clore, Alexander Wlodawer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0078187
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https://doi.org/10.1371/journal.pone.0078187

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