CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells

CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells

Abstract High mortality and low response rates in lung cancer patients call for novel therapeutic targets. Data mining of whole-genome genetic dependency screens suggest Cell Division Cycle 40 (CDC40) to be an essential protein for lung cancer cell survival. We characterized CDC40 knockdown effects...

Full description

Saved in:
Bibliographic Details
Main Authors: Die Hu, Brigitte L. Thériault, Vida Talebian, Laurent Hoffer, Julie Owen, Justin Lim, Benjamin J. Blencowe, Evelyne Lima-Fernandes, Punit Saraon, Richard Marcellus, Rima Al-awar
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-83337-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items