DAGIP: alleviating cell-free DNA sequencing biases with optimal transport

DAGIP: alleviating cell-free DNA sequencing biases with optimal transport

Abstract Cell-free DNA (cfDNA) is a rich source of biomarkers for various pathophysiological conditions. Preanalytical variables, such as the library preparation protocol or sequencing platform, are major confounders of cfDNA analysis. We present DAGIP, a novel data correction method that builds on...

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Main Authors: Antoine Passemiers, Stefania Tuveri, Tatjana Jatsenko, Adriaan Vanderstichele, Pieter Busschaert, An Coosemans, Dirk Timmerman, Sabine Tejpar, Peter Vandenberghe, Diether Lambrechts, Daniele Raimondi, Joris Robert Vermeesch, Yves Moreau
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03511-y
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https://doi.org/10.1186/s13059-025-03511-y

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