Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice.

Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice.

<h4>Aims</h4>Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(-/-)) deficiency on leuko...

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Main Authors: Martine Bot, Paul P Van Veldhoven, Saskia C A de Jager, Jason Johnson, Niels Nijstad, Peter J Van Santbrink, Marijke M Westra, Gerd Van Der Hoeven, Marion J Gijbels, Carsten Müller-Tidow, Georg Varga, Uwe J F Tietge, Johan Kuiper, Theo J C Van Berkel, Jerzy-Roch Nofer, Ilze Bot, Erik A L Biessen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063360&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063360&type=printable

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