Gut microbiota remodeling exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis in prenatal VPA-exposed C57BL/6 mice offspring

Gut microbiota remodeling exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis in prenatal VPA-exposed C57BL/6 mice offspring

IntroductionPrenatal exposure to valproic acid (VPA) is a recognized risk factor for autism spectrum disorder (ASD)-like phenotypes, yet the mechanisms linking gut microbiota dysbiosis to neurodevelopmental impairments remain poorly understood. Emerging evidence implicates the microbiota-gut-brain a...

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Bibliographic Details
Main Authors: Zhaoming Liu, Caixia Wu, Zhaojian Sun, Zuoxian Lin, Yirong Sun, Nouman Amjad, Muhammad Majid, Rajesh Basnet, Zhiyuan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
gut microbiota dysbiosis
cognitive dysfunction
neuroinflammation
prenatal valproic acid exposure
autism spectrum disorder; ASD
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1633680/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1633680/full

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