Interactions between islet-resident macrophages and β cells in diabetes

Interactions between islet-resident macrophages and β cells in diabetes

In diabetes, islet-resident macrophages (IRMs) and β cells engage in multifaceted interactions through diverse signaling pathways and cell–cell contact within the islet microenvironment, jointly shaping both homeostasis and disease progression. This review first outlines the origin, renewal dynamics...

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Bibliographic Details
Main Authors: Danhuai Zhang, Lingzhe Meng, Minghui Xi, Shuai Li, Wantong Chen, LuYi Li, Lingling Dong, Na Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
islet-resident macrophages
β cells
diabetes
cell-cell interaction
immunometabolism
therapeutic targets
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1630507/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1630507/full

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