Bacterial biofilm-derived H-NS protein acts as a defense against Neutrophil Extracellular Traps (NETs)

Abstract Extracellular DNA (eDNA) is crucial for the structural integrity of bacterial biofilms as they undergo transformation from B-DNA to Z-DNA as the biofilm matures. This transition to Z-DNA increases biofilm rigidity and prevents binding by canonical B-DNA-binding proteins, including nucleases...

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Bibliographic Details
Main Authors: AL Hendricks, KR More, A. Devaraj, JR Buzzo, FH Robledo-Avila, S. Partida-Sanchez, LO Bakaletz, SD Goodman
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00691-0
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