Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

Summary: Advancements in human induced pluripotent stem cell (hiPSC) technology have enabled co-culture models for disease modeling in physiologically relevant systems. However, co-culturing protocols face challenges in usability and consistency. Here, we introduce a robust, reproducible hiPSC-deriv...

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Main Authors: Alexandra M. Lish, Nancy Ashour, Richard V. Pearse, II, Paige C. Galle, Gwendolyn A. Orme, Sarah E. Heuer, Courtney R. Benoit, Kellianne D. Alexander, Elyssa F.L. Grogan, Gizem Terzioglu, Allegra Scarpa, Andrew M. Stern, Nicholas Seyfried, Vilas Menon, Tracy L. Young-Pearse
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005480
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