Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics

Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics

Abstract Imaging transcriptomics has become a power tool for linking imaging-derived phenotypes (IDPs) to genomic mechanisms. Yet, its potential for guiding CNS drug discovery remains underexplored. Here, utilizing spatially-dense representations of the human brain transcriptome, we present an analy...

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Main Authors: Christine Ecker, Charlotte M. Pretzsch, Johanna Leyhausen, Lisa M. Berg, Caroline Gurr, Hanna Seelemeyer, Grainne McAlonan, Nicolaas A. Puts, Eva Loth, Flavio Dell’Aqua, Luke Mason, Tony Charman, Bethany Oakley, Thomas Bourgeron, Christian Beckmann, Jan K. Buitelaar, Celso Arango, Tobias Banaschewski, Andreas G. Chiocchetti, Christine M. Freitag, Elke Hattingen, Dilja Krueger-Burg, Michael J. Schmeisser, Jonathan Repple, Andreas Reif, Declan G. Murphy
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61927-3
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https://doi.org/10.1038/s41467-025-61927-3

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