EXPERIMENTAL RATIONALE FOR THE USE OF ROPRENE TO PREVENT ISONIAZID-INDUCED LIVER DAMAGES
A model of isoniazid-induced liver damage in fast (females) and slow (males) acetylators was used to study the preventive hepatoprotective effect of the novel drug roprene in doses of 10, 15, and 30 mg/kg as an oil solution. It was found that in terms of a set of biochemical and morphological criter...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2014-07-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/104 |
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| author | G. N. Mozhokina N. A. Elistratova L. P. Mikhailova O. V. Makarova V. S. Sultanov V. B. Trusov |
| author_facet | G. N. Mozhokina N. A. Elistratova L. P. Mikhailova O. V. Makarova V. S. Sultanov V. B. Trusov |
| author_sort | G. N. Mozhokina |
| collection | DOAJ |
| description | A model of isoniazid-induced liver damage in fast (females) and slow (males) acetylators was used to study the preventive hepatoprotective effect of the novel drug roprene in doses of 10, 15, and 30 mg/kg as an oil solution. It was found that in terms of a set of biochemical and morphological criteria, the most marked hepatoprotective effect of roprene given in a dose of 10 mg/kg and particularly 30 mg/kg was seen in the fast acetylators. In terms of morphological criteria for assessment, the most pronounced hepatoprotective effect of roprene used in a dose of 10 mg/kg and especially 30 mg/kg was observed in the slow acetylators. According to biochemical parameters, there was no advantage of any of the used doses (10, 15, and 30 mg/kg) of roprene in their effect on altered parameters. There is experimental evidence that it is advisable to use roprene to prevent isoniazid-induced hepatotoxicity in the patients with tuberculosis, primarily in the fast acetylators. |
| format | Article |
| id | doaj-art-197820fa1a4a47a78c6587459d441cc4 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-197820fa1a4a47a78c6587459d441cc42025-08-20T02:05:56ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062014-07-0107475310.21292/2075-1230-2014-0-7-42-47104EXPERIMENTAL RATIONALE FOR THE USE OF ROPRENE TO PREVENT ISONIAZID-INDUCED LIVER DAMAGESG. N. Mozhokina0N. A. Elistratova1L. P. Mikhailova2O. V. Makarova3V. S. Sultanov4V. B. Trusov5НИИ фтизиопульмонологии ГБОУ ВПО «Первый МГМУ им. И. М. Сеченова»НИИ фтизиопульмонологии ГБОУ ВПО «Первый МГМУ им. И. М. Сеченова»Научно-исследовательский институт морфологии человека РАМН, г. МоскваНаучно-исследовательский институт морфологии человека РАМН, г. Москва«Солагран Лимитед», Австралия«СолагранСан», г. ТомскA model of isoniazid-induced liver damage in fast (females) and slow (males) acetylators was used to study the preventive hepatoprotective effect of the novel drug roprene in doses of 10, 15, and 30 mg/kg as an oil solution. It was found that in terms of a set of biochemical and morphological criteria, the most marked hepatoprotective effect of roprene given in a dose of 10 mg/kg and particularly 30 mg/kg was seen in the fast acetylators. In terms of morphological criteria for assessment, the most pronounced hepatoprotective effect of roprene used in a dose of 10 mg/kg and especially 30 mg/kg was observed in the slow acetylators. According to biochemical parameters, there was no advantage of any of the used doses (10, 15, and 30 mg/kg) of roprene in their effect on altered parameters. There is experimental evidence that it is advisable to use roprene to prevent isoniazid-induced hepatotoxicity in the patients with tuberculosis, primarily in the fast acetylators.https://www.tibl-journal.com/jour/article/view/104isoniazid-induced hepatotoxicityfast and slow types of acetylationhepatoprotectorsroprene |
| spellingShingle | G. N. Mozhokina N. A. Elistratova L. P. Mikhailova O. V. Makarova V. S. Sultanov V. B. Trusov EXPERIMENTAL RATIONALE FOR THE USE OF ROPRENE TO PREVENT ISONIAZID-INDUCED LIVER DAMAGES Туберкулез и болезни лёгких isoniazid-induced hepatotoxicity fast and slow types of acetylation hepatoprotectors roprene |
| title | EXPERIMENTAL RATIONALE FOR THE USE OF ROPRENE TO PREVENT ISONIAZID-INDUCED LIVER DAMAGES |
| title_full | EXPERIMENTAL RATIONALE FOR THE USE OF ROPRENE TO PREVENT ISONIAZID-INDUCED LIVER DAMAGES |
| title_fullStr | EXPERIMENTAL RATIONALE FOR THE USE OF ROPRENE TO PREVENT ISONIAZID-INDUCED LIVER DAMAGES |
| title_full_unstemmed | EXPERIMENTAL RATIONALE FOR THE USE OF ROPRENE TO PREVENT ISONIAZID-INDUCED LIVER DAMAGES |
| title_short | EXPERIMENTAL RATIONALE FOR THE USE OF ROPRENE TO PREVENT ISONIAZID-INDUCED LIVER DAMAGES |
| title_sort | experimental rationale for the use of roprene to prevent isoniazid induced liver damages |
| topic | isoniazid-induced hepatotoxicity fast and slow types of acetylation hepatoprotectors roprene |
| url | https://www.tibl-journal.com/jour/article/view/104 |
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