Rethinking Radiation Therapy for Perineural Invasion in Oral Cancer: Does More Coverage Improve Outcomes?

Rethinking Radiation Therapy for Perineural Invasion in Oral Cancer: Does More Coverage Improve Outcomes?

ABSTRACT Introduction Perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) is linked to aggressive tumour behaviour and poorer survival outcomes. Adjuvant radiotherapy (RT) is recommended for PNI‐positive OSCC, but optimal RT target volume remains uncertain. Methods This study retrospect...

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Main Authors: Sarbani Ghosh Laskar, Anuj Kumar, Ashwini Adhau, Shwetabh Sinha, Samarpita Mohanty, Munita Bal, Neha Mittal, Swapnil Rane, Asawari Patil, Ashwini Budrukkar, Monali Swain, Pallavi Rane, Gouri Pantvaidya, Sudhir Nair, Deepa Nair, Anuja Deshmukh, Shivakumar Thiagarajan, Richa Vaish, Vidisha Tuljapurkar, Chandrashekhar Dravid, Poonam Joshi, Rathan Shetty, Arjun Singh, Pankaj Chaturvedi
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Cancer Medicine
Subjects:
oral squamous cell carcinoma
perineural invasion
radiation therapy
recurrence patterns
survival outcomes
target volumes
Online Access:https://doi.org/10.1002/cam4.71134
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https://doi.org/10.1002/cam4.71134

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