Assessing the efficacy of varicocelectomy, antioxidants, FSH treatment, and lifestyle modifications on sperm DNA fragmentation: a systematic review and meta-analysis

Assessing the efficacy of varicocelectomy, antioxidants, FSH treatment, and lifestyle modifications on sperm DNA fragmentation: a systematic review and meta-analysis

Abstract Infertility affects 15% of couples in developed countries, 50% accounting for male origin. In 2021, sperm DNA fragmentation (SDF) testing was incorporated into male fertility evaluations as an evidence-based functional test. We aimed to assess the effect of interventions that could potentia...

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Main Authors: Anett Szabó, Szilárd Váncsa, Péter Hegyi, Tamás Kói, Júlia Ács, Réka Juhász Hermánné, Nándor Ács, Tibor Szarvas, Péter Nyirády, Zsolt Kopa
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
DNA fragmentation index
DFI
Male fertility
Subfertility
Varicocele repair
Sperm quality
Online Access:https://doi.org/10.1038/s41598-025-93267-z
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https://doi.org/10.1038/s41598-025-93267-z

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