A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables.

A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables.

The identification and understanding of gene-environment interactions can provide insights into the pathways and mechanisms underlying complex diseases. However, testing for gene-environment interaction remains a challenge since a.) statistical power is often limited and b.) modeling of environmenta...

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Main Authors: Julian Hecker, Dmitry Prokopenko, Matthew Moll, Sanghun Lee, Wonji Kim, Dandi Qiao, Kirsten Voorhies, Woori Kim, Stijn Vansteelandt, Brian D Hobbs, Michael H Cho, Edwin K Silverman, Sharon M Lutz, Dawn L DeMeo, Scott T Weiss, Christoph Lange
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010464&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010464&type=printable

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