Screening of household contacts for TB infection in Cote d'Ivoire

Screening of household contacts for TB infection in Cote d'Ivoire

SETTING: Côte d'Ivoire is a country with a high incidence of TB. The control of TB infection is focused on high-risk patients but has limited implementation. OBJECTIVE: Cost-benefit analysis of TB infection (TBI) screening of household contacts in Côte d’Ivoire to evaluate economic implications...

Full description

Saved in:
Bibliographic Details
Main Authors: R. K. N’Guessan, D. A. B. Orsot, J.M. Ahui Brou, N. K. Bamba, M. E. Tchoutedjem Mefo, A. S. Bakayoko
Format: Article
Language:English
Published: International Union Against Tuberculosis and Lung Disease (The Union) 2024-01-01
Series:IJTLD Open
Subjects:
latent tuberculosis infection
screening
costs
qalys
Online Access:https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00005
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:SETTING: Côte d'Ivoire is a country with a high incidence of TB. The control of TB infection is focused on high-risk patients but has limited implementation. OBJECTIVE: Cost-benefit analysis of TB infection (TBI) screening of household contacts in Côte d’Ivoire to evaluate economic implications of the implementation of interferon-gamma release assays (IGRAs) and the tuberculin skin test (TST). DESIGN: We compared the effectiveness of QuantiFERON-TB Gold Plus (QuantiFERON) with the TST using an economic model previously evaluated in medium TB incidence settings. Principal outcomes relating to TBI screening, as well as the lifetime costs and benefits of the patient cohort, were captured using a decision tree, followed by a Markov model. RESULTS: QuantiFERON proved to be both more effective and less costly than TST. Compared to QuantiFERON, TST use leads to an approximate 33% increase in the lifetime risk of developing active TB. CONCLUSIONS: For household contacts of active TB cases in Côte d’Ivoire, QuantiFERON is cost-effective when compared with TST. R shiny interactive interface enables model customisation for different scenarios, settings, risk groups and TBI screening methods. Further research should be conducted in similar settings to generalise the results.
ISSN:3005-7590

Similar Items