The Resistin/TLR4/miR-155-5p axis: a novel signaling pathway in the onset of hypothalamic neuroinflammation

The Resistin/TLR4/miR-155-5p axis: a novel signaling pathway in the onset of hypothalamic neuroinflammation

Abstract Hypothalamic neuroinflammation plays a pivotal role in the development of metabolic disorders, contributing to obesity and insulin resistance. Hypercaloric diets rich, particularly high-fat diets (HFDs) induce hypothalamic neuroinflammation, which has been shown to precede peripheral inflam...

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Main Authors: Marianne Prévost, Delphine Crépin, Sarah Al Rifai, Ghislaine Poizat, Mélanie Gonçalves, Femke van Barneveld, Rozhina Shadpay, Karim Taouis, Laure Riffault, Yacir Benomar, Mohammed Taouis
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Neuroinflammation
Subjects:
Hypothalamic neuroinflammation
Resistin
miR-155-5p
High fat diet
Glucose intolerance
Online Access:https://doi.org/10.1186/s12974-025-03522-3
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https://doi.org/10.1186/s12974-025-03522-3

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