Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells

Searching for protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells

Abstract Background Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a ubiquitously expressed mitochondrial enzyme with a role in the degradation of fatty acids. Because the protein also is a negative regulator of insulin secretion in pancreatic β-cells, inactivating mutations in the SCHAD gen...

Full description

Saved in:
Bibliographic Details
Main Authors: Kelly Velasco, Janniche Torsvik, Johanna L. St-Louis, Sarah Baghestani, Jonas S. G. Silvander, Rohit N. Kulkarni, Diana M. Toivola, Anders Molven
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Molecular and Cell Biology
Subjects:
Congenital hyperinsulinism of infancy
Short-chain 3-hydroxyacyl-CoA dehydrogenase
SCHAD
HADH
Intermediate filaments
Keratin 8
Online Access:https://doi.org/10.1186/s12860-025-00544-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12860-025-00544-w

Similar Items