Comparative analysis of melatonin’s protective role against flattening filter and flattening filter-free X-ray induced nephropathy: focus on apoptosis and SIRT1 modulation

Abstract Background Radiation-induced nephropathy is a major concern, particularly for patients undergoing radiotherapy. This study investigates melatonin’s (MEL) protective effects against kidney damage induced by Flattening Filter (low dose rate-LDR) and Flattening Filter Free (high dose rate-HDR)...

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Bibliographic Details
Main Authors: Kubra Sevgin, Tansel Sapmaz, Esra Erdem, Sude Topkaraoglu, Kubra Basol Baki, Serhat Aras
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Nephrology
Online Access:https://doi.org/10.1186/s12882-025-04372-0
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