Biliary microbiome profiling via 16 S rRNA amplicon sequencing in patients with cholangiocarcinoma, pancreatic carcinoma and choledocholithiasis

Biliary microbiome profiling via 16 S rRNA amplicon sequencing in patients with cholangiocarcinoma, pancreatic carcinoma and choledocholithiasis

Abstract Recent studies have revealed that oral, gut, and intratumoral microbial dysbiosis significantly affects tumor progression, therapy resistance, and prognosis in cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC) patients. However, the biliary microbiome, which directly inte...

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Main Authors: Hiroki Mizutani, Shunsuke Fukui, Kazuki Oosuka, Kohei Ikeda, Mayu Kobayashi, Yasuaki Shimada, Yuuichi Nakazawa, Yuuki Nishiura, Daisuke Suga, Isao Moritani, Yutaka Yamanaka, Hidekazu Inoue, Hayato Nakagawa, Kaoru Dohi, Hiroyuki Kaiju, Kei Takaba, Hideo Wada, Katsuya Shiraki
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Biliary Microbiome
Cholangiocarcinoma
Pancreatic carcinoma
Choledocholithiasis
16S rRNA gene amplicon sequencing
Online Access:https://doi.org/10.1038/s41598-025-00976-6
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https://doi.org/10.1038/s41598-025-00976-6

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