The type I ribosome-inactivating protein α-MMC induced significant apoptosis of lung cancer A549 and 95-D cells by activating the caspase cascade through TNF signaling pathway

The type I ribosome-inactivating protein α-MMC induced significant apoptosis of lung cancer A549 and 95-D cells by activating the caspase cascade through TNF signaling pathway

Background:Ribosome-inactivating proteins (RIPs) are a class of toxic proteins with RNA N-glycosidase activity, primarily found in plants. Due to their antiviral, antibacterial and anti-tumor biological activities, RIPs have received extensive attention all over the world. Alpha-momorcharin (α-MMC)...

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Bibliographic Details
Main Authors: Di Yang, Di Peng, Houke Li, Di Jia, Yiping Zhou, Bintao Hu, Wei Chen, Yao Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
ribosome-inactivating protein
α-MMC
lung cancer
antitumor activity
apoptosis
signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1529151/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1529151/full

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