Effectiveness of Plasma Therapy in Patients with COVID-19 Infection – A Retrospective Record-based Descriptive Study
Introduction: The COVID-19 pandemic presented an unprecedented challenge to the medical community, leading to numerous therapeutic interventions being explored. Convalescent plasma therapy (CPT), derived from recovered COVID-19 patients, was one such treatment used in the absence of proven therapies...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Acta Medica International |
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| Online Access: | https://journals.lww.com/10.4103/amit.amit_120_24 |
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| author | Murali Shankar Bhat Sripada G. Mehandale Raghavendra R. Huchchannavar |
| author_facet | Murali Shankar Bhat Sripada G. Mehandale Raghavendra R. Huchchannavar |
| author_sort | Murali Shankar Bhat |
| collection | DOAJ |
| description | Introduction:
The COVID-19 pandemic presented an unprecedented challenge to the medical community, leading to numerous therapeutic interventions being explored. Convalescent plasma therapy (CPT), derived from recovered COVID-19 patients, was one such treatment used in the absence of proven therapies. However, its efficacy remained a topic of debate.
Materials and Methods:
This retrospective study aimed to assess the effectiveness of CPT in patients admitted to the intensive care unit (ICU) with moderate-to-severe COVID-19 infection. Data included comorbidities, treatment regimens, partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) ratios, oxygen therapy duration, and outcomes. Patients were divided into groups based on CPT receipt. Statistical analysis was performed to compare the two groups.
Results:
Out of 72 patients, 36 received CPT, and 36 did not. Patients who received CPT had longer ICU and hospital stays. The mortality rate was higher in the CPT group (50%) compared to the non-CPT group (22.2%). Patients with comorbidities experienced higher mortality rates. Notably, the CPT group exhibited improved PaO2/FiO2 ratios on day 2. Complications related to CPT were minimal.
Conclusion:
The use of CPT in COVID-19 treatment did not impact overall survival or hospital stay duration. |
| format | Article |
| id | doaj-art-190de1c11b3e4af384557391924d0c73 |
| institution | Kabale University |
| issn | 2349-0578 2349-0896 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Acta Medica International |
| spelling | doaj-art-190de1c11b3e4af384557391924d0c732025-01-06T14:27:37ZengWolters Kluwer Medknow PublicationsActa Medica International2349-05782349-08962024-12-0111325225510.4103/amit.amit_120_24Effectiveness of Plasma Therapy in Patients with COVID-19 Infection – A Retrospective Record-based Descriptive StudyMurali Shankar BhatSripada G. MehandaleRaghavendra R. HuchchannavarIntroduction: The COVID-19 pandemic presented an unprecedented challenge to the medical community, leading to numerous therapeutic interventions being explored. Convalescent plasma therapy (CPT), derived from recovered COVID-19 patients, was one such treatment used in the absence of proven therapies. However, its efficacy remained a topic of debate. Materials and Methods: This retrospective study aimed to assess the effectiveness of CPT in patients admitted to the intensive care unit (ICU) with moderate-to-severe COVID-19 infection. Data included comorbidities, treatment regimens, partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2) ratios, oxygen therapy duration, and outcomes. Patients were divided into groups based on CPT receipt. Statistical analysis was performed to compare the two groups. Results: Out of 72 patients, 36 received CPT, and 36 did not. Patients who received CPT had longer ICU and hospital stays. The mortality rate was higher in the CPT group (50%) compared to the non-CPT group (22.2%). Patients with comorbidities experienced higher mortality rates. Notably, the CPT group exhibited improved PaO2/FiO2 ratios on day 2. Complications related to CPT were minimal. Conclusion: The use of CPT in COVID-19 treatment did not impact overall survival or hospital stay duration.https://journals.lww.com/10.4103/amit.amit_120_24convalescent plasma therapycovid-19oxygen therapypartial pressure of oxygen/fraction of inspired oxygen ratiosars cov 2 |
| spellingShingle | Murali Shankar Bhat Sripada G. Mehandale Raghavendra R. Huchchannavar Effectiveness of Plasma Therapy in Patients with COVID-19 Infection – A Retrospective Record-based Descriptive Study Acta Medica International convalescent plasma therapy covid-19 oxygen therapy partial pressure of oxygen/fraction of inspired oxygen ratio sars cov 2 |
| title | Effectiveness of Plasma Therapy in Patients with COVID-19 Infection – A Retrospective Record-based Descriptive Study |
| title_full | Effectiveness of Plasma Therapy in Patients with COVID-19 Infection – A Retrospective Record-based Descriptive Study |
| title_fullStr | Effectiveness of Plasma Therapy in Patients with COVID-19 Infection – A Retrospective Record-based Descriptive Study |
| title_full_unstemmed | Effectiveness of Plasma Therapy in Patients with COVID-19 Infection – A Retrospective Record-based Descriptive Study |
| title_short | Effectiveness of Plasma Therapy in Patients with COVID-19 Infection – A Retrospective Record-based Descriptive Study |
| title_sort | effectiveness of plasma therapy in patients with covid 19 infection a retrospective record based descriptive study |
| topic | convalescent plasma therapy covid-19 oxygen therapy partial pressure of oxygen/fraction of inspired oxygen ratio sars cov 2 |
| url | https://journals.lww.com/10.4103/amit.amit_120_24 |
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