SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocity

SNTA1-deficient human cardiomyocytes show shorter field potential duration and slower conduction velocity

Abstract In clinical settings, patients with α-1-syntrophin point mutations are often associated with rare arrhythmias, including Long QT syndrome, Brugada syndrome, and sudden infant death syndrome. Previous studies on α-1-syntrophin have predominantly utilized nonhuman cardiomyocyte models. This s...

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Main Authors: Tao Dong, Yan Zhao, Meng Zhang, Wei-Ya Lang, Dan-Yang Liu, Ke-Shuang Zhang, Yue-Jing Wang, Lin Li, Jie Lian, Hong-Bo Yao, Hai-Yan Zhang, Hai-Feng Jin, Tong Lu, Lei Shen, Li-Ling Yue, Yan Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Human embryonic stem cell
SNTA1-defcient cardiomyocytes
Nav1.5
Field potential duration
Conduction velocity
Online Access:https://doi.org/10.1038/s41598-025-16406-6
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https://doi.org/10.1038/s41598-025-16406-6

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