Mechanism of IGF2BP2 regulation of PPAR-γ/GLUT4 pathway in insulin resistance induced by sodium arsenite exposure in HepG2 cells

Mechanism of IGF2BP2 regulation of PPAR-γ/GLUT4 pathway in insulin resistance induced by sodium arsenite exposure in HepG2 cells

BackgroundArsenic is an environmentally harmful substance that causes hepatic insulin resistance and liver damage, increasing the risk of type 2 diabetes mellitus. ObjectiveTo explore whether the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is involved in insulin resistance in HepG2...

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Bibliographic Details
Main Authors: Shiqing XU, Zhida HU, Qiyao ZHANG, Siqi ZHAO, Yujie WANG, Xiaohui WANG, Teng MA, Li WANG
Format: Article
Language:English
Published: Editorial Committee of Journal of Environmental and Occupational Medicine 2025-04-01
Series:环境与职业医学
Subjects:
sodium arsenite
hepg2 cell
hepatic insulin resistance
type 2 diabetes mellitus
insulin-like growth factor 2 mrna binding protein 2
peroxisome proliferator-activated receptor γ
glucose transporter 4
Online Access:http://www.jeom.org/article/cn/10.11836/JEOM24332
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