Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations

Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations

Sixteen [1, 2, 4]triazolo[4,3-a]quinoxalines as DNA intercalators-Topo II inhibitors have been prepared and their anticancer actions evaluated towards three cancer cell lines. The new compounds affected on high percentage of MCF-7. Derivatives 7e, 7c and 7b exhibited the highest anticancer activitie...

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Bibliographic Details
Main Authors: Alaa Elwan, Helmy Sakr, Abdel-Ghany A. El-Helby, Ahmed El-morsy, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Khaled El-Adl
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Triazoloquinoxaline
docking
DNA intercalators
Topo II inhibitors
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2080205
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https://www.tandfonline.com/doi/10.1080/14756366.2022.2080205

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