Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort
Abstract Background Associations between the overall quality of dietary macronutrients and the odds of hyperlipidemia remain unknown. This study aimed to first investigate the aforementioned associations, applying a novel multidimensional macronutrient quality index (MQI). Methods A large cross-sect...
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BMC
2025-07-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-025-01174-w |
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| author | Xiao-Ying Li Dong-Hui Huang Xin Xu Xi-Meng Zhang Jia-Le Lv Yu-Xin Nan Fan Cao Qi-Jun Wu Yu-Hong Zhao |
| author_facet | Xiao-Ying Li Dong-Hui Huang Xin Xu Xi-Meng Zhang Jia-Le Lv Yu-Xin Nan Fan Cao Qi-Jun Wu Yu-Hong Zhao |
| author_sort | Xiao-Ying Li |
| collection | DOAJ |
| description | Abstract Background Associations between the overall quality of dietary macronutrients and the odds of hyperlipidemia remain unknown. This study aimed to first investigate the aforementioned associations, applying a novel multidimensional macronutrient quality index (MQI). Methods A large cross-sectional study (2018–2020) was carried out among 14,544 participants aged 18–79 years from the NEC-Biobank cohort (Northeast region, China). Dietary information was collected from a validated 110-item food frequency questionnaire. MQI was calculated based on fat quality index (FQI), protein quality index (PQI), and carbohydrate quality index (CQI). Binary logistic regression models were used to assess the odds ratio (OR) with 95% confidence intervals (CI). Results Higher MQI was associated with significantly reduced odds of hyperlipidemia (ORtertile 3 vs. tertile 1 = 0.82, 95% CI: 0.75–0.90; P trend < 0.001). For MQI’s sub-indices, higher FQI (ORtertile 3 vs. tertile 1 = 0.84, 95% CI: 0.77–0.91; P trend < 0.001) as well as higher PQI (ORtertile 3 vs. tertile 1 = 0.86, 95% CI: 0.79–0.94; P trend < 0.001) were associated with lower odds of hyperlipidemia. Conclusions Our findings suggested that intake of high-quality macronutrients was associated with reduced odds of hyperlipidemia. These findings contribute novel knowledge to the field of nutrition and metabolic diseases, and lay the foundation for future studies. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-1900aca4298a4db6912846ad8e157765 |
| institution | DOAJ |
| issn | 1475-2891 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj-art-1900aca4298a4db6912846ad8e1577652025-08-20T03:04:10ZengBMCNutrition Journal1475-28912025-07-0124111210.1186/s12937-025-01174-wAssociations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohortXiao-Ying Li0Dong-Hui Huang1Xin Xu2Xi-Meng Zhang3Jia-Le Lv4Yu-Xin Nan5Fan Cao6Qi-Jun Wu7Yu-Hong Zhao8Department of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Dermatology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityAbstract Background Associations between the overall quality of dietary macronutrients and the odds of hyperlipidemia remain unknown. This study aimed to first investigate the aforementioned associations, applying a novel multidimensional macronutrient quality index (MQI). Methods A large cross-sectional study (2018–2020) was carried out among 14,544 participants aged 18–79 years from the NEC-Biobank cohort (Northeast region, China). Dietary information was collected from a validated 110-item food frequency questionnaire. MQI was calculated based on fat quality index (FQI), protein quality index (PQI), and carbohydrate quality index (CQI). Binary logistic regression models were used to assess the odds ratio (OR) with 95% confidence intervals (CI). Results Higher MQI was associated with significantly reduced odds of hyperlipidemia (ORtertile 3 vs. tertile 1 = 0.82, 95% CI: 0.75–0.90; P trend < 0.001). For MQI’s sub-indices, higher FQI (ORtertile 3 vs. tertile 1 = 0.84, 95% CI: 0.77–0.91; P trend < 0.001) as well as higher PQI (ORtertile 3 vs. tertile 1 = 0.86, 95% CI: 0.79–0.94; P trend < 0.001) were associated with lower odds of hyperlipidemia. Conclusions Our findings suggested that intake of high-quality macronutrients was associated with reduced odds of hyperlipidemia. These findings contribute novel knowledge to the field of nutrition and metabolic diseases, and lay the foundation for future studies. Clinical trial number Not applicable.https://doi.org/10.1186/s12937-025-01174-wCarbohydrate qualityFat qualityHyperlipidemiaMacronutrient qualityProtein quality |
| spellingShingle | Xiao-Ying Li Dong-Hui Huang Xin Xu Xi-Meng Zhang Jia-Le Lv Yu-Xin Nan Fan Cao Qi-Jun Wu Yu-Hong Zhao Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort Nutrition Journal Carbohydrate quality Fat quality Hyperlipidemia Macronutrient quality Protein quality |
| title | Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort |
| title_full | Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort |
| title_fullStr | Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort |
| title_full_unstemmed | Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort |
| title_short | Associations between dietary macronutrient quality and odds of hyperlipidemia: findings from the NEC-Biobank cohort |
| title_sort | associations between dietary macronutrient quality and odds of hyperlipidemia findings from the nec biobank cohort |
| topic | Carbohydrate quality Fat quality Hyperlipidemia Macronutrient quality Protein quality |
| url | https://doi.org/10.1186/s12937-025-01174-w |
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