Stigmasterol alleviates endplate chondrocyte degeneration through inducing mitophagy by enhancing PINK1 mRNA acetylation via the ESR1/NAT10 axis

Stigmasterol alleviates endplate chondrocyte degeneration through inducing mitophagy by enhancing PINK1 mRNA acetylation via the ESR1/NAT10 axis

Intervertebral disc degeneration (IVDD) is a core factor in spinal degeneration. To date, there is no effective treatment for IVDD. It is urgent to identify the pathogenesis of IVDD to develop effective strategies for IVDD treatment. Alleviating endplate chondrocyte degeneration is a promising strat...

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Bibliographic Details
Main Authors: Li Hao, Chen Xiaofeng, Huang Baoci, He Junjie, Xie Junxian, Guo Weijun, Liang Jinjun, Ruan Jiajian, Liu Jincheng, Xiang Zhen, Zhu Lixin
Format: Article
Language:English
Published: De Gruyter 2025-04-01
Series:Open Life Sciences
Subjects:
intervertebral disc degeneration
endplate chondrocyte degeneration
stigmasterol
mitophagy
rna acetylation
Online Access:https://doi.org/10.1515/biol-2022-0913
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https://doi.org/10.1515/biol-2022-0913

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