Deoxyribonuclease Is a Potential Counter Regulator of Aberrant Neutrophil Extracellular Traps Formation after Major Trauma

Introduction. Neutrophil extracellular traps (NET) consist of a DNA scaffold that can be destroyed by Deoxyribonuclease (DNase). Thus DNases are potential prerequisites for natural counter regulation of NETs formation. In the present study, we determined the relationship of NETs and DNase after majo...

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Bibliographic Details
Main Authors: Wei Meng, Adnana Paunel-Görgülü, Sascha Flohé, Ingo Witte, Michael Schädel-Höpfner, Joachim Windolf, Tim Tobias Lögters
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2012/149560
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