Revealing excitation-inhibition imbalance in Alzheimer’s disease using multiscale neural model inversion of resting-state functional MRI

Abstract Background Alzheimer’s disease (AD) is a serious neurodegenerative disorder without a clear understanding of pathophysiology. Recent experimental data have suggested neuronal excitation-inhibition (E-I) imbalance as an essential element of AD pathology, but E-I imbalance has not been system...

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Bibliographic Details
Main Authors: Guoshi Li, Li-Ming Hsu, Ye Wu, Andrea C. Bozoki, Yen-Yu Ian Shih, Pew-Thian Yap
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00736-7
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