Obesity promotes ARDS by modulating ceramide transfer protein-ceramide pathway and exacerbating oxidative stress/apoptosis in alveolar macrophages

Obesity promotes ARDS by modulating ceramide transfer protein-ceramide pathway and exacerbating oxidative stress/apoptosis in alveolar macrophages

Abstract Obesity is an independent risk factor for acute respiratory distress syndrome (ARDS). However, the precise pathway through which obesity amplifies the severity of ARDS remains elusive. Our study embarked on a comprehensive analysis focusing on alterations in the proteomic and metabolomic la...

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Bibliographic Details
Main Authors: Yichan Ao, Jingyue Ma, Xiangyu Hou, Hongbin Li, Zhiqiao Wang, Hanbing Wang, Jianyu He, Siqing Luo, Zikun Duan, Ling Liu, Ke Wei
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
ARDS
Ceramide
CERT
Metabolomics
Obesity
Proteomic
Online Access:https://doi.org/10.1007/s00018-025-05706-9
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https://doi.org/10.1007/s00018-025-05706-9

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