Considerations for homology-based DNA repair in mosquitoes: Impact of sequence heterology and donor template source.

The increasing prevalence of insecticide resistance and the ongoing global burden of vector-borne diseases have encouraged new efforts in mosquito control. For Aedes aegypti, the most important arboviral vector, integration rates achieved in Cas9-based knock-ins so far have been rather low, highligh...

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Bibliographic Details
Main Authors: Joshua Xin De Ang, Katherine Nevard, Rebekah Ireland, Deepak-Kumar Purusothaman, Sebald A N Verkuijl, Lewis Shackleford, Estela Gonzalez, Michelle A E Anderson, Luke Alphey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010060&type=printable
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