Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease

Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease

Abstract Aging increases the risk for Alzheimer’s disease (AD), driving pathological changes like amyloid-β (Aβ) buildup, inflammation, and oxidative stress, especially in the prefrontal cortex (PFC). We present the first subcellular-resolution spatial transcriptome atlas of the human prefrontal cor...

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Main Authors: Yun Gong, Mohammad Haeri, Xiao Zhang, Yisu Li, Anqi Liu, Di Wu, Qilei Zhang, S. Michal Jazwinski, Xiang Zhou, Xiaoying Wang, Kai Zhang, Lindong Jiang, Yi-Ping Chen, Xiaoxin Yan, Russell H. Swerdlow, Hui Shen, Hong-Wen Deng
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54715-y
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https://doi.org/10.1038/s41467-024-54715-y

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