Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease

Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease

Abstract Alpha-synucleinopathies are neurodegenerative diseases characterized by the spread of alpha-synuclein (α-syn) aggregates throughout the central nervous system in a stereotypical manner. These diseases include Lewy body disease (LBD), which encompass Dementia with Lewy bodies (DLB), Parkinso...

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Bibliographic Details
Main Authors: Maria Otero-Jimenez, Marcelina J. Wojewska, Lawrence P. Binding, Simona Jogaudaite, Sandra Gray-Rodriguez, Alexandra L. Young, Steve Gentleman, Javier Alegre-Abarrategui
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Acta Neuropathologica Communications
Subjects:
Alpha-synuclein
Alpha-synucleinopathies
Parkinson’s disease
Astrocytes
Neuroanatomical distribution
Staging
Online Access:https://doi.org/10.1186/s40478-025-01944-x
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https://doi.org/10.1186/s40478-025-01944-x

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