Designed miniproteins potently inhibit and protect against MERS-CoV

Designed miniproteins potently inhibit and protect against MERS-CoV

Summary: Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen with a 36% case-fatality rate in humans. No vaccines or specific therapeutics are currently approved for use in humans or the camel host reservoir. Here, we computationally designed monomeric and homo-oligomeric...

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Main Authors: Robert J. Ragotte, M. Alejandra Tortorici, Nicholas J. Catanzaro, Amin Addetia, Brian Coventry, Heather M. Froggatt, Jimin Lee, Cameron Stewart, Jack T. Brown, Inna Goreshnik, Jeremiah N. Sims, Lukas F. Milles, Basile I.M. Wicky, Matthias Glögl, Stacey Gerben, Alex Kang, Asim K. Bera, William Sharkey, Alexandra Schäfer, Jack R. Harkema, Ralph S. Baric, David Baker, David Veesler
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005315
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http://www.sciencedirect.com/science/article/pii/S2211124725005315

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