Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

Abstract The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor‐tyrosine‐kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature. Using genetic and chemical app...

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Main Authors: Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D Tran, Taekyu Ha, Jing‐Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato
Format: Article
Language:English
Published: Springer Nature 2021-06-01
Series:EMBO Molecular Medicine
Subjects:
cancer
endothelial cells
SHP2
tumor growth
tumor vasculature
Online Access:https://doi.org/10.15252/emmm.202114089
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https://doi.org/10.15252/emmm.202114089

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