LIF Promotes Sec15b‐Mediated STAT3 Exosome Secretion to Maintain Stem Cell Pluripotency in Mouse Embryonic Development

LIF Promotes Sec15b‐Mediated STAT3 Exosome Secretion to Maintain Stem Cell Pluripotency in Mouse Embryonic Development

Abstract LIF maintains self‐renewal growth in mouse embryonic stem cells (mESC) by activating STAT3, which translocates into nucleus for pluripotent gene induction. However, the ERK signaling pathway activated by LIF at large counteract with pluripotent gene induction during self‐renewal growth. Her...

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Main Authors: Li Xu, Jinjun Ji, Lingbo Wang, Jieli Pan, Mingzhe Xiao, Chenxi Zhang, Yihong Gan, Guanqun Xie, Mingdian Tan, Xinchang Wang, Chengping Wen, Yongsheng Fan, Y. Eugene Chin
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
cell pluripotency
exosome
multivesicular endosomes (MVEs)
STAT3
Sec15b
Online Access:https://doi.org/10.1002/advs.202407971
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https://doi.org/10.1002/advs.202407971

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