TLR7 deficiency enhances inflammation in the URT but reduces LRT immunity following influenza A infection

Abstract Immune responses in the upper respiratory tract (URT) following influenza A virus (IAV) infection can influence disease severity, and subsequently inflammation and lung tissue damage in the lower respiratory tract (LRT). This study investigated the role of toll-like receptor 7 (TLR7), a key...

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Bibliographic Details
Main Authors: Mark A. Miles, Sahan Jayawardena, Stella Liong, Felicia Liong, Gemma S. Trollope, John J. O’Leary, Doug A. Brooks, Stavros Selemidis
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-04154-6
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