Porcine Reproductive and Respiratory Syndrome Virus Induces IL-1β Production Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages

Porcine Reproductive and Respiratory Syndrome Virus Induces IL-1β Production Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages

Porcine reproductive and respiratory syndrome virus (PRRSV) is an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. Previous studies have reported that PRRSV infection induced the production of IL-1β. However, the cellular sensors and signaling pathways involve...

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Main Authors: Jing Bi, Shuang Song, Liurong Fang, Dang Wang, Huiyuan Jing, Li Gao, Yidong Cai, Rui Luo, Huanchun Chen, Shaobo Xiao
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2014/403515
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http://dx.doi.org/10.1155/2014/403515

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