Single-Domain Antibodies That Specifically Recognize Intact Capsids of Multiple Foot-and-Mouth Disease Serotype O Strains

Single-Domain Antibodies That Specifically Recognize Intact Capsids of Multiple Foot-and-Mouth Disease Serotype O Strains

Background/Objectives: Intact (146S) foot-and-mouth disease virus (FMDV) particles easily dissociate into 12S particles with a concomitant decreased immunogenicity. Vaccine quality control with 146S-specific single-domain antibodies (VHHs) is hampered by the high strain specificity of most 146S-spec...

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Bibliographic Details
Main Authors: Michiel M. Harmsen, Nishi Gupta, Quillan Dijkstra, Sandra van de Water, Marga van Setten, Aldo Dekker
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
foot-and-mouth disease
vaccine
nanobody
single-domain antibody
antigenicity
Online Access:https://www.mdpi.com/2076-393X/13/5/500
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https://www.mdpi.com/2076-393X/13/5/500

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