Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies

Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies

Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor. Treating this type of cancer is challenging due to its high heterogeneity, rapid cell growth, and highly malignant nature, which results in a poor prognosis. A key feature of GBM’s malignancy is that it resists drug treatment...

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Bibliographic Details
Main Authors: Samine Mashayekhi, Hossein Majedi, Ahmad Reza Dehpour, Samaneh Dehghan, Maryam Jafarian, Mahmoudreza Hadjighassem, Saereh Hosseindoost
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
glioblastoma multiforme
ferroptosis
glutathione depletion
lipid peroxidation
iron metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125002033
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