Is the myonuclear domain ceiling hypothesis dead?

Is the myonuclear domain ceiling hypothesis dead?

Muscle fibres are multinuclear cells, and the cytoplasmic territory where a single myonucleus controls transcriptional activity is called the myonuclear domain (MND). MND size shows flexibility during muscle hypertrophy. The MND ceiling hypothesis states that hypertrophy results in the expansion of...

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Bibliographic Details
Main Authors: Ferdos Aman, Eman El Khatib, Alanood AlNeaimi, Ahmed Mohamed, Alya Sultan Almulla, Amna Zaidan, Jana Alshafei, Omar Habbal, Salma Eldesouki, Rizwan Qaisar
Format: Article
Language:English
Published: Wolters Kluwer – Medknow Publications 2023-07-01
Series:Singapore Medical Journal
Subjects:
muscle hypertrophy
myonuclear domain
satellite cells
skeletal muscle
Online Access:https://journals.lww.com/10.11622/smedj.2021103
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https://journals.lww.com/10.11622/smedj.2021103

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