One-year metreleptin in Colombian sisters with congenital leptin deficiency

One-year metreleptin in Colombian sisters with congenital leptin deficiency

We discovered two adult sisters in Colombia, lineally consanguineous, with severe obesity and undetectable serum leptin levels despite markedly elevated body fat. Their clinical profile included childhood-onset extreme weight gain, intense hunger, hyperphagia, hypogonadotropic hypogonadism, and fami...

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Main Authors: Hernan Yupanqui-Lozno, Jancy Andrea Huertas-Quintero, Maria E. Yupanqui-Velazco, Rocío A. Salinas-Osornio, Carlos M. Restrepo, Adriana Gonzalez, Edna J. Nava-Gonzalez, Luis G. Celis-Regalado, Constanza Neri Morales, Victor M. Hernandez-Escalante, Julio Licinio, Hugo A. Laviada-Molina, Ernesto Rodriguez-Ayala, Carlos Arango, Raul A. Bastarrachea
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Adipocyte
Subjects:
Congenital leptin deficiency
Colombian sisters
LEP gene
recombinant human leptin (metreleptin); leptin replacement therapy
Online Access:https://www.tandfonline.com/doi/10.1080/21623945.2025.2508188
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https://www.tandfonline.com/doi/10.1080/21623945.2025.2508188

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