Alendronate repositioning as potential anti-parasitic agent targeting Trichinella spiralis inorganic pyrophosphatase, in vitro supported molecular docking and molecular dynamics simulation study

Alendronate repositioning as potential anti-parasitic agent targeting Trichinella spiralis inorganic pyrophosphatase, in vitro supported molecular docking and molecular dynamics simulation study

Abstract Trichinellosis represents great public health and economic problems worldwide. Moreover, the development of parasitic resistance against conventional anthelminthic treatment led to the urgent search for new therapeutic strategies, including drug repurposing. Bisphosphonates have been used t...

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Bibliographic Details
Main Authors: Marmar A. Hanafy, Doaa A. Nassar, Fatima M. Zahran, Magdy M. D. Mohammed
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Chemistry
Subjects:
Alendronate
Albendazole
Trichinella spiralis
Scanning electron microscopy
Molecular docking
Molecular dynamics simulation
Online Access:https://doi.org/10.1186/s13065-025-01468-4
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https://doi.org/10.1186/s13065-025-01468-4

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